منابع مشابه
A Read-Through Drug Put through Its Paces
An estimated 10% of all human genetic diseases are caused by nonsense mutations. These look like the stop codons that occur naturally at the ends of proteincoding sequences in our genomes, but they arise instead in the middle of the protein code, with potentially devastating consequences. Instead of faithfully trundling along a gene transcript, translating it into a useful protein product, the ...
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The application of a valve positioning controller (VPC) on top of a basic regulatory plantwide control structure for maximizing the process through-put to increase plant profitability is demonstrated. The input to the VPC is a measurement of the bottleneck constraint and its output is the set-point of the through-put manipulator. The HDA process is used as an example case study with the feed hy...
متن کاملTranslation initiation of IS50R read-through transcripts.
IS50R (and Tn5) normally transposes at a low frequency, partly because cells containing this insertion sequence synthesize low levels of the transposase protein. Since the 5' end of the transposase gene is located next to the outer end of IS50R (and thus close to flanking host sequences), transposition into actively transcribed genes could result in the production of read-through transcripts th...
متن کاملAutomated high through-put colocalization analysis of multichannel confocal images
The laser scanning confocal microscope (LSCM) generates images of multiple labelled fluorescent samples. Colocalization of fluorescent labels is frequently examined. Here we present an example where localization of fluorescent analogues of cloned protein were referenced to fluorescent antibodies directed against the proteins of cellular compartments. Colocalization is usually evaluated by visua...
متن کاملImproving MRCP PACES pass rates through the introduction of a regional multifaceted support framework
INTRODUCTION Practical Assessment of Clinical Examination Skills (PACES) constitutes the final part of the mandatory Royal College of Physicians exam series for progression to higher specialty training. Pass rates were lower for core medical trainees (CMTs) in Coventry and Warwickshire in comparison to other regions within the West Midlands and nationally. OBJECTIVES Our aim was to improve pa...
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ژورنال
عنوان ژورنال: PLoS Biology
سال: 2013
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.1001458